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Results. 32 studies (21 experimental human studies and 11 reviews) were identified. The adverse effects associated with long-term high protein/high meat intake in humans were (a) disorders of bone and calcium homeostasis, (b) disorders of renal function, (c) increased cancer risk, (d) disorders of liver function, and (e) precipitated progression of coronary artery disease.
Conclusions. The findings of the present study suggest that there is currently no reasonable scientific basis in the literature to recommend protein consumption above the current RDA (high protein diet) for healthy adults due to its potential disease risks "
Background. While high-protein consumption—above the current recommended dietary allowance for adults (RDA: 0.8 g protein/kg body weight/day)—is increasing in popularity, there is a lack of data on its potential adverse effects. Objective. To ...
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Tässä rotilla vastaavaa tutkimusta:
Intake of high-protein (HP) diets has increased over the last years, mainly due to their popularity for body weight control. Liver is the main organ h…
www.sciencedirect.com
Tällaisestä puhuttiin taas eräässä paperissa ("Protein and amino acids in nonalcoholic fatty liver disease", doi: 10.1097/MCO.0000000000000706 ), eli aminohappojen aiheuttamat ongelmat:
"Conversely, high protein intake characteristic of the unhealthy Western diet is associated with increased NAFLD prevalence and severity. Plasma concentration of several amino acids, including branched-chain (BCAA) and aromatic amino acids (AAA), is altered in NAFLD. Excess amino acid availability contributes to intrahepatic fat accumulation and may reflect poor dietary habits and dysregulation of amino acid metabolic processing in both liver and peripheral tissues. Specific amino acid patterns, characterized by increased BCAA, AAA, alanine, glutamate, lysine levels, and decreased glycine and serine levels, may be used for early detection of NAFLD and noninvasive assessment of its histological severity. "
Scholarilla löydät toki lisää (valitettavasti itse artikkeleita ei voi tänne linkata, koska ne ovat vain scihubin tai vastaavan takana), mutta paljon uudempaa tutkimusta on kyllä näyttänyt viitteitä, että liikaproteiini on haitallista. Tarkkaa määrää ei toki kukaan osaa sanoa, koska eräässäkin paperissa puhuttiin yli 1,04g/kg keskimääräisestä proteiinimäärästä per päivä jossa havaittiin ongelmia (tuo on keskimääräinen amerikkalaisen saama proteiinimäärä per päivä).
Kyllähän näitä löytyy.